11-06-2022 New members of the Tewhey Lab!
We would like to welcome our new lab members Niketa and Frank! Niketa is a first year PhD student in the Tufts Mammalian Genetics program at JAX and Frank is a summer student in the JAX Summer Student Program. You can learn more about Frank and Niketa here.
05-05-2022 Autoimmune GWAS work published at Nature Genetics
Postdoctoral Associate Kousuke Mouri’s first author paper “Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells” is now out at Nature Genetics. Using MPRA, 18,000 GWAS variants across 6 T-cell autoimmune diseases were tested for functional activity, leading to the identification of 60 putatively causal variants and development of a mouse model for the risk allele of a prioritized variant near BACH2. This work was in collaboration with Dr. John Ray’s laboratory at the Benaroya Research Institute.
05-05-2022 Tewhey Lab featured on the JAX website
The Tewhey Lab was featured on the JAX website. Read the article here to learn more about our work on regulatory elements, collaborative efforts on Type II Diabetes and auto-immune disease, and Ryan’s scientific journey.
11-02-2022 MPRAduo Preprint
Our work on characterizing genome-wide RE1 silencers using MPRAduo is out on Biorxiv. Our team modified MPRA to test repressive elements and characterized ~13000 human RE1. You can read the preprint here.
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