Still Harbor by Tom Curry Still Harbor by Tom Curry

Welcome to the Tewhey Lab

We are a group of human geneticist, molecular biologists and computational scientists interested in understanding how genetic variation impacts human traits and risk to disease.
Our lab is located in the Snell Building on the Bar Harbor Campus of The Jackson Laboratory.

What’s new with us?

11-06-2022     New members of the Tewhey Lab!
We would like to welcome our new lab members Niketa and Frank! Niketa is a first year PhD student in the Tufts Mammalian Genetics program at JAX and Frank is a summer student in the JAX Summer Student Program. You can learn more about Frank and Niketa here.

05-05-2022     Autoimmune GWAS work published at Nature Genetics
Postdoctoral Associate Kousuke Mouri’s first author paper “Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells” is now out at Nature Genetics. Using MPRA, 18,000 GWAS variants across 6 T-cell autoimmune diseases were tested for functional activity, leading to the identification of 60 putatively causal variants and development of a mouse model for the risk allele of a prioritized variant near BACH2. This work was in collaboration with Dr. John Ray’s laboratory at the Benaroya Research Institute.

05-05-2022     Tewhey Lab featured on the JAX website
The Tewhey Lab was featured on the JAX website. Read the article here to learn more about our work on regulatory elements, collaborative efforts on Type II Diabetes and auto-immune disease, and Ryan’s scientific journey.

11-02-2022     MPRAduo Preprint
Our work on characterizing genome-wide RE1 silencers using MPRAduo is out on Biorxiv. Our team modified MPRA to test repressive elements and characterized ~13000 human RE1. You can read the preprint here.

Check here for more updates from the Tewhey Lab

Contact Us

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The Tewhey Lab is also associated with
Tufts and The University of Maine

Mailing/Shipping:
600 Main St
Bar Harbor ME 04609

email: info (at) tewheylab.org