Congratulations to Ryan, who just gave his promotion seminar for Associate Professor at JAX! The title of his talk was “Defining the genetic basis of complex traits and disease through the (de)coding of regulatory syntax.”
Congratulations to Ryan, who just gave his promotion seminar for Associate Professor at JAX! The title of his talk was “Defining the genetic basis of complex traits and disease through the (de)coding of regulatory syntax.”
Our work on characterizing genome-wide RE1 silencers using MPRAduo is out in Cell Genomics! Our team, lead by post-doc Kousuke Mouri, modified MPRA to test repressive elements and characterized ~13000 human RE1. You can read the paper here
We would like to welcome our new lab members Niketa and Frank! Niketa is a first year PhD student in the Tufts Mammalian Genetics program at JAX and Frank is a summer student in the JAX Summer Student Program.
The Tewhey Lab was featured on the JAX website. Read the article [here] (https://www.jax.org/news-and-insights/2022/may/genome-explorer) to learn more about our work on regulatory elements, collaborative efforts on Type II Diabetes and auto-immune disease, and Ryan’s scientific journey.
Postdoctoral Associate Kousuke Mouri’s first author paper “Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells” is now out at Nature Genetics. Using MPRA, 18,000 GWAS variants across 6 T-cell autoimmune diseases were tested for functional activity, leading to the identification of 60 putatively causal variants and development of a mouse model for the risk allele of a prioritized variant near BACH2. This work was in collaboration with Dr. John Ray’s laboratory at the Benaroya Research Institute.