News from the Tewhey Lab


HCR-FlowFISH preprint is live

Ryan Tewhey
12 May 2020

We have released our preprint on bioRxiv describing HCR-FlowFISH, a flexible phenotyping method for CRISPRi/a screens of cis-regulatory elements. This project is in collaboration with Steve Reilly and Pardis Sabeti at the Broad Institute and part of our work as an ENCODE Characterization Center.


Natalia Fuentes Awarded NSF Summer Fellowship

Susan Kales
09 May 2020

COVID-19 has upturned many people’s summer/internship plans including Natalia’s. She was initially intending to spend the summer break working on wildlife conservation in Madagascar! Unfortunately, the program was cancelled but lucky for all of us she is back in Maine and will continue working in the lab this summer. Natalia also applied for NSF funding and was recently awarded a fellowship for the summer! Natalia will be extending the work she started last summer as an SSP student investigating synthetic regulatory elements.


New collaboration studying gene regulation of autoimmune disease

Ryan Tewhey
01 March 2020

We are excited to start a new project with the Siggers and Emili labs at Boston University looking at how cis-regulatory elements are impacted by genetic variation associated with autoimmune diseases. This work is funded by a new R01 awarded to the Siggers lab from the NIH/NIAID. We’re looking forward to a fun five years exploring the regulatory architecture of these regions!


MPRA of T2D elements in islets now on in bioRxiv

Ryan Tewhey
13 February 2020

The first project we started when joining JAX was a collaboration with the Stitzel lab at JAX-GM to look at T2D risk variants in beta islet cells. Due to the hard work of Shubham Khetan a grad student in the Ucar and Stitzel labs we now have a preprint in bioRxiv describing our initial work.


Hannah Completed Second Masters Degree

Susan Kales
17 December 2019

Hannah has completed her second masters degree, with distinction, from Queens University Belfast in Northern Ireland. This comes after having completed a project identifying genes which can potentially help physicians identify drug resistance in kidney cancer patients before treatment, as well as investigating the efficacy of drug combinations in resistant and susceptible cell lines.