Our work on characterizing genome-wide RE1 silencers using MPRAduo is out on Biorxiv. Our team modified MPRA to test repressive elements and characterized ~13000 human RE1. You can read the preprint here
Our work on characterizing genome-wide RE1 silencers using MPRAduo is out on Biorxiv. Our team modified MPRA to test repressive elements and characterized ~13000 human RE1. You can read the preprint here
Our work describing HCR-FlowFISH as a flexible phenotyping methods for CRISPR non-coding screens is now out at Nature Genetics. Our article made the cover with a beautiful illustration from our friends at SciStories. Check it out here. This work was a collaboration between the Sabeti Lab at the Broad Institute and the Reilly Lab at Yale University.
Postdoc Kousuke Mouri is a first author on a new preprint in collaboration with Dr. John Ray’s laboratory at the Benaroya Research Institute using MPRA to localize genome wide association signals of T-cell mediated autoimmune disorders. In addition, we knock-out a cis-regulatory element that influences expression of Bach2 and show it plays a role in CD8 T-cell biology. You can read the preprint here.
The Tewhey Lab’s partnership with the Maine CDC was featured on the front page of the PPH in an article describing how Maine is well prepared for COVID-19 genomic surveillance. Read the article here.
We just uploaded a preprint describing our work, in collaboration with the Sabeti Lab using MPRA to functionally test human variation residing 3’ UTR. You can read the preprint here.