Postdoc Kousuke Mouri is a first author on a new preprint in collaboration with Dr. John Ray’s laboratory at the Benaroya Research Institute using MPRA to localize genome wide association signals of T-cell mediated autoimmune disorders. In addition, we knock-out a cis-regulatory element that influences expression of Bach2 and show it plays a role in CD8 T-cell biology. You can read the preprint here.
The Tewhey Lab’s partnership with the Maine CDC was featured on the front page of the PPH in an article describing how Maine is well prepared for COVID-19 genomic surveillance. Read the article here.
We just uploaded a preprint describing our work, in collaboration with the Sabeti Lab using MPRA to functionally test human variation residing 3’ UTR. You can read the preprint here.
The Tewhey Lab is working with the Maine CDCP to sequence positive COVID-19 cases within the state of Maine. Our work will help develop an epidemiological narrative based on the genetic fingerprint of the virus in order to better understand how the virus is circulating.
We would like to welcome our new lab members John and Luke who did rotations with us over the winter. John joins us from the Graduate School of Biomedical Science and Engineering at the University of Maine, and Luke joins us from Tufts. Both will be working on continuations of their rotation projects, and we look forward to seeing where they will go!